Date December 20, 2021
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Grants totaling $4.6 million support the use of machine learning to improve outcomes of people with HIV

In partnership with Moi University in Kenya, 腾讯五分彩官网 will develop, test and launch data-driven tools to maximize the effectiveness of HIV care programs.

PROVIDENCE, R.I. [腾讯五分彩官网] — Over the past four decades of treating HIV/AIDS, 已经确定的两个重要事实是:hiv阳性患者需要在确诊后立即接受治疗,然后继续实施有效的治疗计划. 这种反应可以帮助将艾滋病毒转变为一种慢性但可控的疾病,基本上可以帮助人们过上正常的生活, healthy lives, 腾讯五分彩官网公共卫生和生物统计学教授约瑟夫·霍根说, who has been researching HIV/AIDS for 25 years.

霍根是美国国立卫生研究院(National Institutes of Health)最近授予的两项基金的主要研究人员之一, totaling nearly $4.6 million over five years, 支持数据驱动工具的创建和利用,使肯尼亚的护理项目能够实现这些关键的治疗目标.

“If the system works as designed, then we have confidence that we’ll improve the health outcomes of people with HIV,” Hogan said.

该项目的第一部分涉及使用数据科学来理解所谓的艾滋病护理级联, said Hogan, 他是“提供医疗保健服务的学术模式”生物统计项目的联合主任(AMPATH), 一个由14所北美大学组成的联盟,与埃尔多雷特的莫伊大学合作, Kenya, on HIV research, care and training.

Hogan will collaborate with longtime scientific partner Ann Mwangi, associate professor of biostatistics at Moi University, who received a Ph.D. in biostatistics from Brown in 2011. Using AMPATH-developed electronic health record database, 由Hogan和Mwangi共同领导的团队将开发基于算法的统计机器学习工具,以预测患者何时以及为何可能放弃护理,以及他们的病毒载量水平何时表明他们面临治疗失败的风险.

These algorithms, Hogan said, 然后会整合到电子健康记录系统中,在护理点传递信息吗, 通过手持平板电脑,医生可以在检查室与病人一起使用. In consultation with experts in user interface design, 该团队将评估和测试最有效的方法,将算法的结果传达给护理提供者,以便他们可以使用它们来做出有关病人护理的决定, Hogan said.

The predictive modeling system the team is developing, Hogan said, 是否会在护理点提醒医生病人治疗计划中的危险信号. This way, interventions can be developed to help a patient get to their treatment appointments, for example, before the patient needs to miss or cancel them. Or if a patient is predicted to have high viral load, Hogan said, 临床医生可以推荐他们进行额外的监测,在其成为问题之前识别并治疗这种增长.

“ With this project, we hope to bring the promise of A.I. 将机器学习应用到患者和临床层面,并评估开发出来的工具,这些工具将对患者的结果产生可衡量的影响. ”

Joseph Hogan 腾讯五分彩官网生物统计学教授,AMPATH生物统计学项目联合主任

“这个想法是,医生将能够使用算法的结果,以看到在护理点哪些病人处于危险之中, and then, be able to take preventive actions to avoid the negative outcomes, rather than respond to negative outcomes after they happen,” Hogan said.

目标不仅包括开发复杂的算法,还包括将它们付诸实践和评估它们的临床价值. 这是统计学和机器学习领域的腾讯五分彩官网与医疗信息学开发人员以及临床医生之间真正的合作, Hogan said. Hamish Frasier, associate professor in the Brown Center for Biomedical Informatics and an expert in open-source medical records systems, will lead development of the user-interface system to be used at the point of care.

“With this project, we hope to bring the promise of A.I. 将机器学习应用到患者和临床层面,并评估开发出来的工具,这些工具将对患者的结果产生可衡量的影响,” Hogan said.

腾讯五分彩官网 has a long-standing, multi-dimensional relationship with AMPATH that involves collaborative research 由国家卫生研究院资助的特定流行病学和临床研究问题. 布朗公共卫生学院和沃伦·阿尔珀特医学院也通过涉及医学生和住院医生的交换项目与AMPATH合作, and partnerships related to clinical care programs in HIV, oncology, tuberculosis and others.    

Hogan and Mwangi co-lead a research training program, known as NAMBARI, supported by a federal grant from the NIH Fogarty International Center, to advance biostatistics training and research capacity at Moi University. The program is a partnership between Moi University and 腾讯五分彩官网, and provides both long- and short-term training for students, faculty and technical staff in Kenya.

这项新研究拨款的一个重要特点是,与算法开发和实施相关的许多技术工作将由在腾讯五分彩官网接受NAMBARI项目培训的肯尼亚统计学家在埃尔多雷特现场进行. The Kenyan team members will be led by Mwangi.

In addition to Hogan, Mwangi and Fraser, the team includes Tao Liu, Allison DeLong, Rami Kantor, Arman Oganisian of Brown; Jonathan Dick of Indiana University School of Medicine; Jonathan Teich of Brigham and Women’s Hospital; and Lameck Diero and Juddy Wachira of Moi University.

本研究由美国国立卫生研究院研究资助项目1R01AI167694-01和培训资助项目2D43TW010050-06资助.